|Eng Lo (Chair)|
|Hiroyuki Kinouchi, Hidehiko Okazawa (Co-Chairs)|
|Rick Dijkhuizen (Chair)|
|Jun Chen||Introduction (5 min)|
Jens Dreier is professor at the Center for Stroke Research Berlin where he leads the research group Translation in Stroke Research (TSR) (www.schlaganfallcentrum.de/index.php?id=221). We investigate whether observations in the lab may have relevance for the clinic or whether diagnostic applications can be translated from bench to bedside. For this purpose, my group is concerned with both experimental work in animals and human and rodent brain slices, and with translational clinical studies. Our focus is on delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH) because it represents a model disease for hypoxic-ischemic injury. Our translational clinical studies are embedded in the Co-Operative Studies on Brain Injury Depolarizations (COSBID) (www.cosbid.org).
Three selected publications:
Lückl J, Lemale CL, Kola V, Horst V, Khojasteh U, Oliveira-Ferreira AI, Major S, Winkler MKL, Kang EJ, Schoknecht K, Martus P, Hartings JA, Woitzik J, Dreier JP (2018) The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex. Brain 141:1734-1752
Dreier JP, Reiffurth C (2015) The stroke-migraine depolarization continuum. Neuron 86:902-922
Dreier JP (2011) The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 17:439-447
Dr. Lyden holds the Carmen and Louis Warschaw Chair in Neurology. Dr. Lyden helped lead the pivotal NINDS t-PA for Acute Stroke Trial, the first proven therapy for stroke, and edited the premier text on thrombolytic therapy for acute stroke, now in its 3rd Edition. He is recognized globally for leadership in stroke therapy, having led large, multi-national trials for NIH and industry. He is widely recognizable for producing and directing the NIH Stroke Scale training and certification videos, which have been viewed almost 2 million times around the world. The NIHSS has been translated into 2 dozen languages and remains the de facto standard for rating stroke severity.
Dr. Lyden received his medical training from the Baylor College of Medicine in Houston, followed by internship, neurology residency, and Stroke Fellowship in San Diego. From 1987 to 2009 he was a member of the Neurosciences faculty at UCSD and directed the Stroke Research Center from 1994 to 2009. He also served as staff physician at the Veteran’s Affairs Medical Center; Chief of Neurology and Director of the Stroke Center at the UCSD Medical Center; and Professor in the Department of Neurosciences at UCSD. In 2009 he moved to Cedars-Sinai Medical Center in Los Angeles and founded the Department of Neurology, the Comprehensive Stroke Center, the Neurology Residency, and the Fellowship in Stroke Neurology. In 2018 he returned full time to research and patient care.
Dr. Lyden's research has been continuously Federally funded for over 30 years, and Dr. Lyden has co-authored over 350 papers and book chapters. His laboratory focuses on the mechanisms of injury to the neurovascular unit. Recently, the group characterized the toxic role played by neuronally-derived thrombin and showed evidence of direct thrombin toxicity on neurons. Thrombin is made by injured neurons, and signals astrocytes to elicit a protective response.
Dr. Lyden has been elected a Fellow of the American Academy of Neurology, American Neurology Association, American Heart Association, and the European Stroke Organization. In 2019 he was awarded the prestigious William M. Feinberg Award for Excellence in Clinical Stroke by the American Heart Association.
|Richard Carson||Introduction (5 min)|
Mohamad El Amki is a researcher at the Neurology Department at the University Hospital of Zürich and the University of Zürich. His current research focuses on investigating how the vessels in the brain react after stroke and how tissue reperfusion could be improved. In addition to his work on brain blood flow and cerebrovascular changes, he also uses motor rehabilitation strategies to elucidate how neuronal circuits compensate after stroke.Dr. Amki received his B.Sc. and M.Sc. in Pathophysiology from the Lebanese University of Beirut and the Saint Joseph University in 2008. From Lebanon, he moved to work in Paris at the Sorbonne Paris Descartes University, where he completed his Masters in Pharmacology in 2009 and received his Doctoral degree in 2013. Before moving to Switzerland, he completed his postdoctoral training in the Normandy at the University of Rouen in 2015 where he investigated the effect of vasospasm in SAH stroke. Dr. Amki has published numerous papers on a variety of topics related to ischemic and hemorrhagic stroke.
Rick Dijkhuizen is professor of Experimental and Translational Neuroimaging, and head of the Biomedical MR Imaging and Spectroscopy group, part of the Center for Image Sciences, at the University Medical Center Utrecht (The Netherlands). His research focuses on multiparametric imaging of brain structure and function in health and disease, with particular emphasis on i) development of tools for improved diagnosis of brain pathophysiology, ii) characterization of neural network (re)organization, and iii) monitoring of neuroprotective and -restorative therapies. He has been particularly involved in preclinical MRI studies to get improved insights in stroke pathophysiology and recovery.Rick Dijkhuizen collaborates with various national and international institutions on topics such as stroke recovery, brain repair and functional imaging. He is Associate Editor of Frontiers in Neurology/Stroke and the Journal of Cerebral Blood Flow and Metabolism.
Neuroenergetics, or understanding how the brain produces energy to maintain its functions, has attracted much attention recently. From the improvement of cognitive performances through lifestyle changes (e.g. exercise and nutrition) to novel neuroprotective strategies against neurodegenerative diseases, it appears that neuroenergetics is central for several and diverse aspects of neurobiology. More particularly, studying the cellular links between neuronal activity and energy homeostasis is of utmost importance to elucidate the mechanisms of energy supply dictated by costly neuronal activity. It has also direct impact for neuroprotection
|1983||graduated with an MD from Miyazaki Medical College.|
|1983-87||Residency at the Department of Obstetrics and Gynecology, Osaka University and affiliated hospital|
|1987||Lecturer at Department of Obstetrics and Gynecology, Miyazaki Medical College, starting research on maternal and fetal medicine under Professor Tsuyomu Ikenoue|
|1984-96||studied fetal physiology using sheep fetus at University of California, Irvine under Professor Yuji Murata|
|2005-2011||Director of Obstetrics and Gynecology at National Cardiovascular Center in Osaka.|
|2010-2011||Director of Regenerative Medicine at National Cardiovascular Center.|
|2011-preent||Professor and Chairman i, Department of Obstetrics and Gynecology, Mie University.|
At UCSF I have served as the Director of Research, Neonatal Brain Disorders Center, since 2003. I have served on the NIH study sections and chaired Brain 2 and Brain 3 Committees for the AHA.With my multi-disciplinary training in chemistry, biochemistry, pharmacology and physiology, for more than 25 years I have centered my research on the mechanisms of experimental stroke, including the role of cerebrovascular injury and neuroinflammation. In particular, my laboratory has focused on the mechanisms of perinatal stroke and, most recently, on childhood stroke. We were the first to establish age-appropriate focal stroke models in neonatal rats and mice to mimic perinatal stroke and in juvenile mice to mimic childhood stroke. We demonstrated a strikingly better preserved blood-brain barrier integrity after acute perinatal stroke compared to that after adult stroke. We discovered that microglial cells serve as endogenous neuroprotectants following perinatal stroke. We are currently investigating the contribution of microglial-extracellular matrix interactions in long-term injury in perinatal and childhood stroke.
Andre Obenaus, Ph.D. is currently Professor in the Department of Pediatrics, School of Medicine at University of California, Irvine (UCI). He is also Director of the Preclinical and Translational Imaging Center at UCI. His B.Sc. degree was obtained in Biophysics at La Sierra University (1984) and his Ph.D. was obtained from the University of British Columbia in Neurophysiology (1989). Postdoctoral research was completed at the University of California, Los Angeles understanding the anatomical and physiological basis underlying epilepsy.
Currently, his research interests include the use of novel magnetic resonance imaging approaches to non-invasively identify the evolution of neuropathology and how the brain responds to therapeutic interventions. Funded research investigates the influence of vascular alterations in brain trauma, non-invasive and predictive biomarkers relevant to febrile seizures and subsequent development of epilepsy, the evolution of white matter loss in adult and juvenile brain following neurotrauma, and novel therapeutic compounds for mitigating the effects of stroke, among others. Research into how the brain circuitry is modified by episodes of early life adversity are ongoing as part of the Conte Center @ UCI. Most recently, Dr. Obenaus is a member of the MODEL AD consortia that seeks to phenotype relevant rodent models of Alzheimer’s disease using novel MRI approaches. The use of automated computer vision techniques for analysis of biomedical data is a continuing research interest. He has extensive collaborations with national and international researchers to compliment and extend these research endeavors. His research has been and is currently funded by NIH, NSF, DOD, NASA and others. Further he has served as a grant reviewer for both national and international funding agencies. He has been invited as a speaker to national and international conferences and has been invited to speak at academic institutions worldwide.He currently has over 165 peer-reviewed publications and 15 published book chapters on a range of research interests encompassing brain trauma, neonatal and adult stroke and epilepsy. He also serves on the editorial boards of 4 journals of international societies. He currently holds a number of patents on computer vision techniques for analysis of magnetic resonance images and one on combinatorial therapies for stroke.
I am currently a postdoctoral researcher at the Institute for Stroke and Dementia at the Klinikum der Universität München, Germany. My expertise lies at the crossroad of neurobiology and immunology, where I am mainly investigating how we can modulate the immune response to brain injury in order to improve the outcome of stroke. In particular, my research focuses on the critical role of the gut microbiota as immunomodulators in stroke disease.
Commensal gut bacteria have a profound impact on health and diseases. We and others have shown that intestinal microbiota influences stroke pathophysiology by modulating the peripheral immune system (Benakis et al. Nat Med 2016; Singh et al. J Neurosci 2016). Moreover, the gut microbiota produces several immunoactive metabolites which may impact on recovery from stroke.In this session, I will summarize the current findings on the molecular pathomechanisms of the microbiota-brain interaction focusing on the metabolites and immune polarization in the context of acute brain injuries. We will examine the impact of these recent insights on generating a novel concept of a bi-directional communication along the “brain-gut-microbiome-immune” axis in stroke.
|Thomas P Davis||Introduction|
|Raymond Koehler, Paco Herson (co-chairs)|
Dr. Stefanovic is a senior scientist in Physical Sciences at Sunnybrook Research Institute, and an associate professor in the Department of Medical Biophysics at the University of Toronto. Dr. Stefanovic’s research focuses on the development of new methods for quantitative in vivo imaging of brain function. Her research interests include the development and application of in vivo high field functional MRI, two-photon fluorescence microscopy, and extracellular recordings for tracking functional deficits in cellular components of the neurovascular unit over the course of neurodegeneration in transgenic models of Alzheimer’s Disease and during chronic stage of recovery in rodent models of focal ischemia and traumatic brain injury.Relevant expertise/areas of interest: functional MRI, two photon fluorescence microscopy, neurovascular unit, Alzheimer's disease, stroke recovery, TBI imaging.
Academic and work experience
|1982-1988||Kyoto University, School of Medicine|
|1991-1995||Kyoto University, School of Medicine, Graduate School (Neurological Science)|
|1995-2007||Hamamatsu City Medical Corporation, Positron Medical Center, Chief|
|1997-2000||Hawaii Queen's Medical Center, Collaborative researcher|
|2004-present||Hamamatsu Medical Photonics Foundation, Director|
Hamamatsu University School of Medicine,
Department of Biofunctional Imaging, Professor
|Kuniyasu Niizuma, Jun Chen (Co-Chairs)|
|2004||M.D.||Faculty of Medicine, Kyushu University|
Department of Medicine and Clinical Science,
Graduate School of Medical Sciences, Kyushu University
|2004-2007||Resident||Departments of Cerebrovascular disease,
Kyushu Medical Center, Cerebrovascular center
|2011-||Researcher||Precursory Research for Embryonic Science and
Technology (PRESTO), Japan Science and Technology
|2015-||Lecturer||Department of Microbiology and Immunology,
School of Medicine, Keio University
|2017-||Project Leader||Stroke Renaissance Project, Tokyo Metropolitan Institute
of Medical Science
Major publicationsShichita T, et al. Nat Med. 23:723-732 (2017)
|Zsuzsanna Fabry||Introduction (10 min)|
Dr. Benveniste is the Senior Vice Dean for Basic Sciences at the UAB School of Medicine (SOM). She was the Founding Chair of the Department of Cell, Developmental and Integrative Biology (2012-2015), and served as Chair of the Department of Cell Biology (2000-2011). Benveniste also holds the Charlene A. Jones Endowed Chair in Neuroimmunology.
During her postdoctoral studies, in the Department of Neurology at the University of California Los Angeles (UCLA), Benveniste initiated research on elucidating the mechanisms by which cells of the immune system and the central nervous system communicate and influence functionality, cytokine/chemokine production by glial cells, the effects of cytokines/chemokines on glial cell function, and the ability of glial cells to function as immune effector cells in the brain. This research continues to date. These studies have implications for autoimmune/neurodegenerative diseases such as Multiple Sclerosis and Parkinson’s Disease, and cancers such as brain tumors.
Dr. Benveniste’s research is supported by two NIH RO1s, grants from the Michael J. Fox Foundation and the National Multiple Sclerosis Society, and is a Project Leader on the Alabama Udall Center Award.
Benveniste has served on the editorial boards of multiple journals including The Journal of Immunology, Journal of Neuroscience, and Journal of Biological Chemistry and is currently on the editorial boards of the Journal of Neuro-Virology and Journal of Neuroinflammation. She was elected in 2009 as a Fellow of the American Association for the Advancement of Science (AAAS). With 32 years of peer-review panel experience, Benveniste continues as a reviewer for panels such as the Michael J. Fox Foundation, National Multiple Sclerosis Society, NIH Neurological Science and Disorders Committee C, and the NIH Directors Transformative Research Award Committee.